Today, we're gonna talk about statin drug side effects. I wanted to expand on some of the mechanisms of the side effects and talk about why we really need to understand how all this works.
Here are some of the most commonly recognized side effects.
- Liver Damage and Muscle Damage(Heart)
- Memory, Concentration, Depression
- Pain, Peripheral Neuropathy
- Sleep problems, Sexual Dysfunction and Fatigue
- Guaranteed reduction of CoQ10 Mitochondria
These are just the main reported ones but the mechanism behind that there's a guaranteed thing that happens And that is that it's going to reduce the amount of CoQ10. It's a very important enzyme that's vital for energy production in Mitochondria.
Where do you need it? The most you need it in the organs that use the most energy, which is your liver, heart, and brain pretty important organs.
This is all based on something called Mevalonate Pathway and you don't have to understand these words. But I just kind of put them in there so that you know that there's something going on.
So HMG-CoA Reductase that's an enzyme that's involved with producing mevalonic acid and then there are a couple of intermediaries that are not important at all that lead up to something called farnesyl PP. This in turn becomes squalene, which is a greasy substance that the body uses to make cholesterol, and then the same substance is also used to make CoQ10.
These two things compete for resources. But when you take a statin drug now the statin acts on this enzyme and it inhibits it. So, a chemical substance that interferes with something in the body is called poison. That's essentially what these things are. So, by blocking this enzyme, you're stopping this entire pathway and therefore your body is no longer able to make The same amount of precursor for the cholesterol and the CoQ10.
The body doesn't go through all this trouble to make something that's harmful. It makes the exact right proportions and amounts of LDL and HDL cholesterol of all the different sizes depending on what's going on in the body, depending on what the needs are to repair inflammation and provide precursors to hormones and all these different things.
It's a very fine-tuned mechanism. If you eat less cholesterol, your body makes more because it's an essential nutrient. Your brain is 60-70% fat and 25% of that is cholesterol. Again that's not a mistake. It's an essential nutrient. So when we interfere with the production of this enzyme, we're not just interfering with one essential nutrient called cholesterol. Were also shutting down energy production by interfering with the production of CoQ10.
So now if we just go back to this list and we look at liver damage, muscle damage, heart memory, concentration, depression, most of those are because the brain needs both cholesterol and CoQ10. It needs cholesterol as building products and precursors and it needs CoQ10 to make energy 95% of the energy in your body comes from the oxidation of fuel with the help of oxygen.
If you don't have the CoQ10 you're going to reduce that amount of energy production and again your brain, your heart, and your liver use the most energy because they're the most metabolically active organs that you have. So when you interfere with the building materials and the energy production. Now you get damaged in all these vital organs. These essential organs provide essential functions.
But here's the thing to think about. Even if you don't have a side effect, even if you don't notice some symptoms, are you better or worse off if your body has to have something and you interfere with the production of it, Are you better or worse off? Of course, So what that means. And in terms of every medication versus virtually because the mechanism is to interfere with a pathway in the body with the metabolic function. And if the body is trying to do something, it's not by mistake, it's doing it on purpose and by interfering with the mechanism we are interfering with something the body feels is essential to do. In every case you're worse off whether you get noticeable symptoms or side effects or not when you interfere with the body, when you reduce something that the body has to have, then you're worse off. So that's something to keep in mind.
Of course, there is always a time and place for medication, but it's for life-saving, not for metabolic and lifestyle imbalances the way to correct this.